Psychedelic: 4-HO-MET Vendor. Buy 4-HO-MET
Introduction to 4-HO-MET
4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine), also known as metocin, is a synthetic psychedelic compound belonging to the tryptamine class. It’s structurally similar to psilocin, the active compound in psilocybin mushrooms, and was first synthesized by chemist Alexander Shulgin
Chemical Profile of 4-HO-MET
- Class: Psychedelic tryptamine
- Structure: Analog of psilocin
- Mechanism: Likely acts as a partial agonist at serotonin receptors, especially 5-HT2A, which is associated with psychedelic effects
Origin of 4-HO-MET
The Man and His Rediscovery
Alexander “Sasha” Shulgin (1925–2014) was a pioneering American chemist and pharmacologist best known for his synthesis and personal exploration of hundreds of psychoactive compounds, particularly in the phenethylamine and tryptamine families leading to the discovery of 4-HO-MET amongst many others.
Key Contributions: Rediscovery of MDMA
- Shulgin is credited with reintroducing MDMA (Ecstasy) to the scientific and therapeutic community in the late 1970s.
- He advocated for its use in psychotherapy, especially for enhancing emotional communication.
Alexander Shulgin’s influence on psychedelic therapy is profound and enduring. Here’s how his work shaped the field:
Compounds He Created or Popularized
Shulgin synthesized and explored over 230 psychoactive compounds, many of which are still studied today. Some of the most notable include:
| Compound | Class | Known Effects |
| MDMA | Empathogen | Emotional openness, reduced fear, enhanced communication |
| 2C-B | Phenethylamine | Visuals, euphoria, mild stimulation |
| DOM | DOx family | Long-lasting visuals, altered time perception |
| 4-HO-MET | Tryptamine | Psilocin-like visuals, shorter duration |
| 5-MeO-DiPT | Tryptamine | Auditory distortions, body sensations |
| 2C-T-7 | Phenethylamine | Introspection, visuals, potential toxicity at high doses |
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Each compound was meticulously documented in his books PiHKAL and TiHKAL, which include synthesis instructions, dosage guidelines, and subjective trip reports
Influence on Psychedelic Therapy: Scientific Legacy
- Shulgin’s self-experimentation and detailed documentation laid the groundwork for modern psychedelic pharmacology.
- His work inspired researchers to explore psychedelics as therapeutic tools for depression, PTSD, anxiety, and addiction.
Therapeutic Philosophy
- He believed psychedelics could unlock deep emotional and spiritual insights, especially when used in safe, intentional settings.
- His wife, Ann Shulgin, was a Jungian lay therapist who used MDMA and 2C-B in therapeutic sessions, helping clients explore their unconscious and shadow selves
Cultural Impact
- Shulgin’s home lab, known as “The Farm,” became a hub for scientists, therapists, and psychonauts.
- His open sharing of chemical knowledge fostered a community of responsible exploration, influencing groups like MAPS (Multidisciplinary Association for Psychedelic Studies)
Enduring Legacy
- Shulgin is often called the “Godfather of Ecstasy” for his role in bringing MDMA to therapeutic use.
- His work continues to inspire the psychedelic renaissance, with clinical trials now exploring compounds he first synthesized.
- His books remain seminal texts for chemists, therapists, and psychonauts alike.
Effects
| Positive Effects | Negative Effects |
| Visual hallucinations | Nausea |
| Enhanced creativity | Muscle tension |
| Euphoria | Paranoia |
| Ego dissolution | Temperature dysregulation |
| Connection with nature | Delusions (at high doses) |
Users often describe the experience as visually intense but less psychologically heavy than psilocybin mushrooms
Duration & Dosage
- Onset: 15–40 minutes
- Peak: 2–3 hours
- Total duration: 4–6 hours
- After-effects: May linger for 2–12 hours
- Common dosage: 10–20 mg orally; higher doses (20–30 mg) yield stronger effects
Safety & Legality
- Legality: Varies by country; legal in some regions as a research chemical
- Toxicity: No known lethal dose; generally considered non-toxic at standard doses
- Risks: As with all psychedelics, psychological vulnerability and set/setting play a major role in the experience.
Author of PiHKAL & TiHKAL :Together with his wife Ann Shulgin, he wrote:
- PiHKAL: Phenethylamines I Have Known and Loved
- TiHKAL: Tryptamines I Have Known and Loved
These books are part autobiography, part chemistry manual, documenting the synthesis and subjective effects of numerous compounds.
Shulgin Rating Scale
He developed a scale to quantify the intensity and nature of psychedelic experiences, which became widely used in psychopharmacology.
Shulgin Philosophy & Legacy
- Shulgin believed in cognitive liberty—the right to explore one’s own consciousness.
- He tested most of his creations on himself, starting with microdoses and meticulously recording effects.
- His work laid the foundation for modern psychedelic research and inspired generations of scientists, therapists, and psychonauts.
