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Introduction to 4-HO-MET

 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine), also known as metocin, is a synthetic psychedelic compound belonging to the tryptamine class. It’s structurally similar to psilocin, the active compound in psilocybin mushrooms, and was first synthesized by chemist Alexander Shulgin

 Chemical Profile of 4-HO-MET

• Class: Psychedelic tryptamine
• Structure: Analog of psilocin
• Mechanism: Likely acts as a partial agonist at serotonin receptors, especially 5-HT2A, which is associated with psychedelic effects

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 Origin of 4-HO-MET

 The Man and His Rediscovery

Alexander “Sasha” Shulgin (1925–2014) was a pioneering American chemist and pharmacologist best known for his synthesis and personal exploration of hundreds of psychoactive compounds, particularly in the phenethylamine and tryptamine families leading to the discovery of 4-HO-MET amongst many others.

Key Contributions: Rediscovery of MDMA

• Shulgin is credited with reintroducing MDMA (Ecstasy) to the scientific and therapeutic community in the late 1970s.
• He advocated for its use in psychotherapy, especially for enhancing emotional communication.

 Alexander Shulgin’s influence on psychedelic therapy is profound and enduring. Here’s how his work shaped the field:

Compounds He Created or Popularized

Shulgin synthesized and explored over 230 psychoactive compounds, many of which are still studied today. Some of the most notable include:

Compound	Class	Known Effects
MDMA	Empathogen	Emotional openness, reduced fear, enhanced communication
2C-B	Phenethylamine	Visuals, euphoria, mild stimulation
DOM	DOx family	Long-lasting visuals, altered time perception
4-HO-MET	Tryptamine	Psilocin-like visuals, shorter duration
5-MeO-DiPT	Tryptamine	Auditory distortions, body sensations
2C-T-7	Phenethylamine	Introspection, visuals, potential toxicity at high doses

 

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Each compound was meticulously documented in his books PiHKAL and TiHKAL, which include synthesis instructions, dosage guidelines, and subjective trip reports

Influence on Psychedelic Therapy: Scientific Legacy

• Shulgin’s self-experimentation and detailed documentation laid the groundwork for modern psychedelic pharmacology.
• His work inspired researchers to explore psychedelics as therapeutic tools for depression, PTSD, anxiety, and addiction.

Therapeutic Philosophy

• He believed psychedelics could unlock deep emotional and spiritual insights, especially when used in safe, intentional settings.
• His wife, Ann Shulgin, was a Jungian lay therapist who used MDMA and 2C-B in therapeutic sessions, helping clients explore their unconscious and shadow selves

Cultural Impact

• Shulgin’s home lab, known as “The Farm,” became a hub for scientists, therapists, and psychonauts.
• His open sharing of chemical knowledge fostered a community of responsible exploration, influencing groups like MAPS (Multidisciplinary Association for Psychedelic Studies)

 Enduring Legacy

• Shulgin is often called the “Godfather of Ecstasy” for his role in bringing MDMA to therapeutic use.
• His work continues to inspire the psychedelic renaissance, with clinical trials now exploring compounds he first synthesized.
• His books remain seminal texts for chemists, therapists, and psychonauts alike.

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 Effects

Positive Effects	Negative Effects
Visual hallucinations	Nausea
Enhanced creativity	Muscle tension
Euphoria	Paranoia
Ego dissolution	Temperature dysregulation
Connection with nature	Delusions (at high doses)

Users often describe the experience as visually intense but less psychologically heavy than psilocybin mushrooms

Duration & Dosage

• Onset: 15–40 minutes
• Peak: 2–3 hours
• Total duration: 4–6 hours
• After-effects: May linger for 2–12 hours
• Common dosage: 10–20 mg orally; higher doses (20–30 mg) yield stronger effects

Safety & Legality

• Legality: Varies by country; legal in some regions as a research chemical
• Toxicity: No known lethal dose; generally considered non-toxic at standard doses
• Risks: As with all psychedelics, psychological vulnerability and set/setting play a major role in the experience.

Author of PiHKAL & TiHKAL :Together with his wife Ann Shulgin, he wrote:

• PiHKAL: Phenethylamines I Have Known and Loved
• TiHKAL: Tryptamines I Have Known and Loved

These books are part autobiography, part chemistry manual, documenting the synthesis and subjective effects of numerous compounds.

Shulgin Rating Scale

He developed a scale to quantify the intensity and nature of psychedelic experiences, which became widely used in psychopharmacology.

Shulgin Philosophy & Legacy

• Shulgin believed in cognitive liberty—the right to explore one’s own consciousness.
• He tested most of his creations on himself, starting with microdoses and meticulously recording effects.
• His work laid the foundation for modern psychedelic research and inspired generations of scientists, therapists, and psychonauts.